c. AD 46-48
Paul and Barnabas set out from Antioch on the first organized missionary journey, traveling through Cyprus and southern Asia Minor (modern Turkey). They established churches in Pisidian Antioch, Iconium, Lystra, and Derbe despite fierce opposition.
The first missionary journey established the pattern for intentional, strategic church planting. Paul's practice of preaching first in synagogues, then to Gentiles, and appointing elders in each new church became the model for Christian expansion.
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